Hexapeptide 8

Hexapeptide-8, commonly known as Argireline, is a synthetic peptide celebrated for its potential benefits in skincare formulations. Commonly referred to as “Botox in a jar” because it inhibits the release of neurotransmitters and relaxes the facial muscles, thus reducing expression lines and wrinkles.


  • Reduction of Expression Lines: Hexapeptide-8 works by inhibiting neurotransmitter release, particularly the release of acetylcholine. This action helps relax facial muscles, diminishing the appearance of expression lines, such as forehead wrinkles, crow's feet, and frown lines.
  • Softening of Dynamic Wrinkles: By moderating muscle contractions, Hexapeptide-8 aids in softening dynamic wrinkles caused by repetitive facial movements. It targets specific areas where muscle movement leads to the formation of lines, contributing to a smoother, more youthful complexion.
  • Anti-Ageing Effects without Injections: Argireline's ability to mitigate muscle movements mimics the effects of some injectable wrinkle relaxers, offering a topical alternative without the need for invasive procedures or injections.
  • Hydration and Skin Smoothing: While primarily targeting expression lines, Hexapeptide-8 may also support skin hydration and promote a smoother skin surface, enhancing overall skin texture and radiance.



https://pubmed.ncbi.nlm.nih.gov/24754410/ https://pubmed.ncbi.nlm.nih.gov/23417317/ https://www.ncbi.nlm.nih.gov/m/pubmed/29371611/?i=1&from=Argireline