Panthenol/ Vitamin E5

etabolises in the skin to form Pantothenic Acid. It is a deep penetration moisturiser that stimulates cell proliferation and promotes minor wound healing.  It acts as an anti-inflammatory agent and is effective in treating acute sunburn.

 

Benefits:

  •  Hydration Dynamics: At the crux of panthenol's efficacy is its role as a humectant. Upon topical application, panthenol is converted into pantothenic acid, an integral component of coenzyme A, crucial for cellular metabolism. This process enhances the skin's water retention capacity, fostering deep hydration by attracting and binding water molecules. The resultant augmentation of the skin's natural moisture barrier contributes significantly to improved hydration levels.
  • Anti-Inflammatory Mechanisms: Panthenol's anti-inflammatory properties stem from its ability to modulate various cytokines and mediators involved in the inflammatory cascade. Through the inhibition of pro-inflammatory pathways, panthenol mitigates redness and irritation, offering therapeutic relief for individuals with inflammatory skin conditions. This nuanced anti-inflammatory action positions panthenol as a valuable asset in formulations targeting dermatoses and compromised skin barriers.
  • Wound Healing Acceleration: The accelerated wound healing attributed to panthenol can be elucidated through its involvement in cellular proliferation and tissue repair processes. By facilitating fibroblast proliferation and collagen synthesis, panthenol expedites the regeneration of damaged skin. The molecular cascade initiated by panthenol contributes to efficient wound closure, reducing the risk of scarring and promoting optimal skin restoration.
  • Epidermal Barrier Enhancement: A critical facet of panthenol's impact lies in its role in bolstering the epidermal barrier. Pantothenic acid, derived from panthenol, participates in the synthesis of lipids crucial for maintaining the skin barrier's integrity. This reinforcement translates into improved barrier function, limiting trans-epidermal water loss and fortifying the skin against environmental stressors.
  • Anti-Ageing Attributes: Panthenol's contributions to anti-aging skincare are rooted in its humectant properties and support of skin barrier function. By preserving optimal hydration levels and fortifying the skin matrix, panthenol aids in diminishing the appearance of fine lines and wrinkles. Its compatibility with other anti-aging actives further positions it as an ally in formulations designed for age-related skin concerns.
  • Environmental Defence Mechanisms: Panthenol's protective role against environmental stressors is orchestrated through its impact on the skin's antioxidant defences. By mitigating oxidative stress and bolstering the skin's resilience, panthenol aids in safeguarding against the deleterious effects of UV radiation, pollution, and other environmental aggressors.

 

Sources:

https://pubmed.ncbi.nlm.nih.gov/21982351/